Emily Loffredo, University of New Hampshire

Class Year:



Mary Haasch, Ph.D.

Project Title:

Comparisons of the Effects of Peroxisome Agents on the Embryo and Post-Hatch Larvae of the Non-Responsive Orzyias latipes and the Responsive Fundulus heteroclitus


In this study, embryo-larval assays were carried out with two species of fish; the mummichog, Fundulus heteroclitus, and the Japanese Medaka, Oryzias latipes. Fertilized eggs were collected, and embryos were exposed to two peroxisome proliferating chemicals; Clofibrate and Dibutyl Phtalate. The embryos were examined under a microscope through their development, and deformities were noted. In general, results were inconclusive. A slight trend was seen in the Diburyl Phthalate study towards higher instance of deformities in medaka embyros exposed to DBP. Both species had high mortality at the 10ppm treatment of each chemical, and Dibutyl Phthalate seemed to be a stronger PPA than Clofibrate.

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