Research Publications: UM-SG-RS-2004-19


The zebrafish as a model for studying skeletal development.




Du, SJ; Haga, Y


Baeuerlein, E, ed. Biomineralization Progress in Biology, Molecular Biology and Application. Wiley-VCH.
Chapter 17 : 283 - 304


The skeleton is a specialized tissue that, together with cartilage, makes up the skeletal system that confers multiple mechanical and biological functions, such as providing a support site for muscle attachment, protecting vital organs (e.g. brain) or cells (e.g. bone marrow) and serving as a reserve of ions. The important function of bone can be easily recognized in day-to-day life, where millions of people suffer from bone disease such as osteoporosis, that is, in part, caused by an imbalance between bone formation and bone resorption. A better understanding of the regulation of bone formation will provide important insights into the molecu1ar mechanisms of bone disease and give rise to novel strategies for new drug design. Zebrafish have become an excellent model for systematic screening for mutations affecting different aspects of embryonic development including bone formation. Many of the point mutations that were created in fish more closely resemble human skeletal dysplasias. This chapter describes the embryonic origins and molecular regulation of bone formation in zebrafish. This review is primarily focused on recent studies that have taken advantage of the simple embryology and genetic tractability of zebrafish to dissect the cellular and molecular mechanisms underlying osteogenesis.

Related Research Project(s) Funded by Maryland Sea Grant:

Maryland Sea Grant Topic(s):

'Related Research Project(s)' link to details about research projects funded by Maryland Sea Grant that led to this publication. These details may include other impacts and accomplishments resulting from the research.

'Maryland Sea Grant Topic(s)' links to related pages on the Maryland Sea Grant website.

The Blue Crab: Callinectes Sapidus

An essential resource for researchers, students, and managers.  Get your copy today!

pile of cooked crabs

5825 University Research Court, Suite 1350 | College Park, MD 20740 | Phone: (301) 405-7500 | Fax: (301) 314-5780 | Contact Us

  • Twitter
  • Facebook
  • YouTube
  • Flickr
  • RSS