R/A-01

The gonadotropin-releasing hormone (GnRH) System of striped bass: Endocrine, molecular and applied studies

Principal Investigator:

Yonathan Zohar

Start/End Year:

2000 - 2002

Institution:

Center of Marine Biotechnology, University of Maryland Biotechnology Institute

Topic(s):

Description:

1. To study interactions between analogs of the striped bass native GnRHs and their receptor, in order to tailor a physiologically-compatible spawning induction therapy based on analogs of the most relevant and potent GnRHs and their optimal delivery pattern. 2. To continue studying the regulation of the synthesis and release of the endogenous GnRHs in striped bass, in order to understand the mechanisms underlying captivity-induced impairment of the GnRH system and the "repair" effect of an exogenous GnRH therapy.

Related Publications:

Yonathan, Z; Tal, Y; Schreier, H; Steven, C; Stubblefield, J; Place, A. 2005. Commercially feasible urban recirculating aquaculture: addressing the marine sector. Costa-Pierce, B; Desbonnet, A; Edwards, P; Baker, D, eds. Urban Aquaculture. CAB International.Chapter 10:159 -171. UM-SG-RS-2005-27.

Wong, TT; Gothilf, Y; Zmora, N; Kight, KE; Meiri, I; Elizur, A; Zohar, Y. 2004. Developmental expression of three forms of gonadotropin-releasing hormone and ontogeny of the hypothalamic-pituitary-gonadal axis in Gilthead Seabream (Sparus aurata). Biology of Reproduction71(3):1026 -1035. doi:10.1095/biolreprod.104.028019. UM-SG-RS-2004-04.

Steven, C; Lehnen, N; Kight, K; Ijiri, S; Klenke, U; Harris, WA; Zohar, Y. 2003. Molecular characterization of the GnRH system in zebrafish (Danio rerio): cloning of chicken GnRH-II, adult brain expression patterns and pituitary content of salmon GnRH and chicken GnRH-II. General and Comparative Endocrinology133(1):27 -37. doi:10.1016/S0016-6480(03)00144-8. UM-SG-RS-2003-28.

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