R/ODR-09

Comparative Pathogenesis of P. marinus disease in bivalves: Development of Prevention Strategies for C. virginica

Principal Investigator:

Robert S. Anderson

Start/End Year:

1997 - 2000

Institution:

Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science

Topic(s):

Description:

To identify the basis of P. marinus pathogenicity to C virginica the following host-parasite interactions will be quantified in P. marinus susceptible and -resistant bivalves: phagocytosis and antimicrobial activity, effects of cellular and serum factors on parasite replication, and the production of host immunoregulatory molecules by P. marinus The in vivo effects of b-glucan, a stimulator of antimicrobial activity, administration will be evaluated on the progression and lethality of dermo disease.

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