Mercenaria mercenaria - QPX: Immunological characterization of the host-pathogen interface

Principal Investigator:

Robert S. Anderson

Start/End Year:

2000 - 2003


Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science

Co-Principal Investigator:

Sharon E. McGladdery, Gulf Fisheries Centre



QPX is an emerging disease affecting cultured M. mercenaria from Atlantic Canada to Virginia. The major objective is to understand the hosts' defense responses to QPX. Specifically, a suite of hemocytic and serum-dependent immune mechanisms will be quantified and evaluated with regard to resistance to this protistan parasite. Parameters of immunity involved with non-self recognition, inhibition of replication, and killing of QPX organisms by circulating blood cells and serum macromolecules will be measured.

Related Publications:

Anderson, RS; Kraus, BS; McGladdery, S; Smolowitz, R. 2003. QPX, a pathogen of quahogs (hard clams), employs mucoid secretions to resist host antimicrobial agents. Journal of Shellfish Research22(1):205 -208. UM-SG-RS-2003-14.

Anderson, RS; Kraus, BS; McGladdery, SE; Reece, KS; Stokes, NA. 2003. A thraustochytrid protist isolated from Mercenaria mercenaria: molecular characterization and host defense responses. Fish & Shellfish Immunology15(3):183 -194. doi:10.1016/S1050-4648(02)00157-2. UM-SG-RS-2003-10.

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