Science Serving Maryland's Coasts

R/ODR-18

Intracellular Survival of Perkinsus Marinus: The Oxidative Stress Pathway As A Potential Target For Therapy

Principal Investigator: 

Gerardo R. Vasta

Start/End Year: 

2001 to 2004

Institution: 

Center of Marine Biotechnology, University of Maryland Biotechnology Institute

Co-Principal investigator: 

Eric J. Schott, Jose A. Fernandez-Robledo, Wolf T. Pecher, Center of Marine Biotechnology, University of Maryland Biotechnology Institute

Topic(s): 

Description: 

Using knowledge of the P. marinus-C. virginica interaction, we will discover strategies to disadvantage the parasite, whether by identification of parasite targets for drug therapy, or by augmentation of host defense responses. We will complete the characterization of APX, including subcellular localization, catalytic properties, and structure; study the effect of environmental and host factors on Fe-SOD and APX expression in P. marinus; examine if C. virginica possess Fe-SOD and APX activities, and if does, find differences between host and parasite in the localization or biochemical characteristics of these enzymes; and explore ways to stimulate ROI production by hemocytes.

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