Science Serving Maryland's Coasts

R/F-91

Mercenaria mercenaria - QPX: Immunological characterization of the host-pathogen interface

Principal Investigator: 

Robert S. Anderson

Start/End Year: 

2000 to 2003

Institution: 

Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science

Co-Principal investigator: 

Sharon E. McGladdery, Gulf Fisheries Centre

Topic(s): 

Description: 

QPX is an emerging disease affecting cultured M. mercenaria from Atlantic Canada to Virginia. The major objective is to understand the hosts' defense responses to QPX. Specifically, a suite of hemocytic and serum-dependent immune mechanisms will be quantified and evaluated with regard to resistance to this protistan parasite. Parameters of immunity involved with non-self recognition, inhibition of replication, and killing of QPX organisms by circulating blood cells and serum macromolecules will be measured.

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