Comparative studies of macrophage function: Bivalve hemocyte chemiluminescence
Principal Investigator:Robert S. Anderson
Start/End Year:1991 to 1994
Institution:Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science
The main objective is to carry out comparative studies of the effects of metals and other chemicals on macrophage immune functions using mammalian and aquatic invertebrate animal models. This is part of a collaborative study to determine the potential for interspecies extrapolation of immunotoxicological data, in an attempt to develop models using alternative species for toxicity testing. Immunosuppressive effects of chemical exposure on bivalve blood cells (this proposal) will be compared to those produced by the same chemicals on rat alveolar macrophages (carried out by collaborators at the U.S. Army Chemical Research, Development and Engineering Center).