Science Serving Maryland's Coasts

R/CT-01

Enhancing Fish Muscle Growth through Blocking Myostatin Function

Principal Investigator: 

Shao-Jun Du

Start/End Year: 

2004 to 2006

Institution: 

Center of Marine Biotechnology, University of Maryland Biotechnology Institute

Description: 

The objective of this study is to determine the expression and function of a muscle growth inhibitor named Myostatin in zebrafish. The specific objectives are: 1). To determine the expression of endogenous Myostatin and Myostatin prodomain transgene in fish growing under various conditions, and to determine the optimal condition for enhancing fish muscle growth through inhibition of Myostatin function. 2). To study the mechanism by which Myostatin inhibits muscle growth, and to determine if inhibiting Myostatin function results in increased MyoD expression and myoblast proliferation.

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