The novel gonadotropin-releasing hormone (GnRH) of fish: its functions, regulation of synthesis and release, and potential use for spawning manipulations in striped bass
Principal Investigator:Yonathan Zohar
Start/End Year:1996 to 2001
Institution:Center of Marine Biotechnology, University of Maryland Biotechnology Institute
Co-Principal investigator:Thomas T. Chen, University of Connecticut, Biotechology Center
To study the biological activity of the novel GnRH in striped bass and to design and select super-active analogs of this peptide to be used for improved spawning induction therapies in striped bass and other farmed fish. To study the regulation of the synthesis and release of the novel GnRH in striped bass, in order to understand the nature of the hormonal failure that results in the lack of ovulation and spawning in captive striped bass and other farmed marine fish. Improve the technology for spawning induction in striped bass, based on the administration of super-active analogs of the most physiologically relevant sbGnRH, or of the most potent cGnRH-II, at the appropriate dose, pattern and timing. The tested hypothesis is that a fully physiologically-compatible GnRH-based technology will optimally induce spawning in captive striped bass. Continue our studies towards understanding the nature of the GnRH failure that results in the lack of ovulation and spawning in captive striped bass and other farmed fish. The tested hypothesis is that a failure to synthesize or release the relevant sbGnRH is the reason for the lack of spawning in captive striped bass.
Klenke, U; Zohar, Y. 2003. Gonadal regulation of gonadotropin subunit expression and pituitary Lh protein content in female hybrid striped bass. Fish Physiology and Biochemistry 28(14):25-27. doi:10.1023/B:FISH.0000030465.56876.97. UM-SG-RS-2003-15.