Science Serving Maryland's Coasts

R/BT-05

Red drum growth hormone: Heterologous production in a eukaryotic expression system, physiology, and effects on growth after dietary administration

Principal Investigator: 

John J. Trant

Start/End Year: 

1996 to 2001

Institution: 

Center of Marine Biotechnology, University of Maryland Biotechnology Institute

Topic(s): 

Description: 

To evaluate several biotechnology approaches for producing biologically active recombinant red drum growth hormone (GH), to understand the physiology of GH secretion and the possible functions of GH in red drum, and to determine whether feeding the recombinant hormone in the diet is an effective method for administering GH and promoting growth of fish. Long-term goals are to develop techniques for mass producing piscine recombinant growth hormones inexpensively, to undertake a comprehensive investigation of the functions of GH using the recombinant hormone, as well as developing a practical method for administering them to fish at commercial aquaculture facilities to enhance fish growth.