Intracellular Survival of Perkinsus Marinus: The Oxidative Stress Pathway As A Potential Target For Therapy
Using knowledge of the
Perkinsus marinus-Crassotrea virginica interaction, we will discover strategies to disadvantage the parasite, whether by identification of parasite targets for drug therapy, or by augmentation of host defense responses. We will complete the characterization of APX, including subcellular localization, catalytic properties, and structure; study the effect of environmental and host factors on Fe-SOD and APX expression in
P. marinus; examine if
C. virginica possess Fe-SOD and APX activities, and if does, find differences between host and parasite in the localization or biochemical characteristics of these enzymes; and explore ways to stimulate ROI production by hemocytes.
|
Gerardo R. Vasta and Eric J. Schott
University of Maryland Biotechnology Institute
|
|
|
