Enhancing Fish Muscle Growth through
Blocking Myostatin Function
The objective of this study is to determine the expression and function of a muscle growth inhibitor named Myostatin in zebrafish. The specific objectives are: 1). To determine the expression of endogenous Myostatin and Myostatin prodomain transgene in fish growing under various conditions, and to determine the optimal condition for enhancing fish muscle growth through inhibition of Myostatin function. 2). To study the mechanism by which Myostatin inhibits muscle growth, and to determine if inhibiting Myostatin function results in increased
MyoD expression and myoblast proliferation.
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Shao-Jun Du
Center of Marine Biotechnology
University of Maryland Biotechnology Institute
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